Genetic alterations of triple negative breast cancer by targeted next-generation sequencing and correlation with tumor morphology.

ABSTRACT: Triple negative breast cancer represents a heterogeneous group of breast carcinomas, both at the histologic and genetic level. Although recent molecular studies have comprehensively characterized the genetic landscape of these tumors, few have integrated a detailed histologic examination into the analysis. In this study, we defined the genetic alterations in 39 triple negative breast cancers using a high-depth targeted massively parallel sequencing assay and correlated the findings with a detailed morphologic analysis. We obtained representative frozen tissue of primary triple negative breast cancers from patients treated at our institution between 2002 and 2010. We characterized tumors according to their histologic subtype and morphologic features. DNA was extracted from paired frozen pri

SUBMITTER: Weisman PS 

PROVIDER: S-EPMC4848211 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature