Natural History of Aerosol Exposure with Marburg Virus in Rhesus Macaques.

ABSTRACT: Marburg virus causes severe and often lethal viral disease in humans, and there are currently no Food and Drug Administration (FDA) approved medical countermeasures. The sporadic occurrence of Marburg outbreaks does not allow for evaluation of countermeasures in humans, so therapeutic and vaccine candidates can only be approved through the FDA animal rule-a mechanism requiring well-characterized animal models in which efficacy would be evaluated. Here, we describe a natural history study where rhesus macaques were surgically implanted with telemetry devices and central venous catheters prior to aerosol exposure with Marburg-Angola virus, enabling continuous physiologic monitoring and blood sampling without anesthesia. After a three to four day incubation period, all animals developed fever

SUBMITTER: Ewers EC 

PROVIDER: S-EPMC4848582 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature