MiR-210 promotes sensory hair cell formation in the organ of corti.

ABSTRACT:

Background

Hearing loss is the most common sensory defect afflicting several hundred million people worldwide. In most cases, regardless of the original cause, hearing loss is related to the degeneration and death of hair cells and their associated spiral ganglion neurons. Despite this knowledge, relatively few studies have reported regeneration of the auditory system. Significant gaps remain in our understanding of the molecular mechanisms underpinning auditory function, including the factors required for sensory cell regeneration. Recently, the identification of transcriptional activators and repressors of hair cell fate has been augmented by the discovery of microRNAs (miRNAs) associated with hearing loss. As miRNAs are central players of differentiation and cell fate, identific

SUBMITTER: Riccardi S 

PROVIDER: S-EPMC4848794 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature