Identification of Serum Peptidome Signatures of Non-Small Cell Lung Cancer.

ABSTRACT: Due to high mortality rates of lung cancer, there is a need for identification of new, clinically useful markers, which improve detection of this tumor in early stage of disease. In the current study, serum peptide profiling was evaluated as a diagnostic tool for non-small cell lung cancer patients. The combination of the ZipTip technology with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) for the analysis of peptide pattern of cancer patients (n = 153) and control subjects (n = 63) was presented for the first time. Based on the observed significant differences between cancer patients and control subjects, the classification model was created, which allowed for accurate group discrimination. The model turned out to be robust enough to discrimin

SUBMITTER: Klupczynska A 

PROVIDER: S-EPMC4848884 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature