Linear and Branched PEIs (Polyethylenimines) and Their Property Space.

ABSTRACT: A chemical property space defines the adaptability of a molecule to changing conditions and its interaction with other molecular systems determining a pharmacological response. Within a congeneric molecular series (compounds with the same derivatization algorithm and thus the same brute formula) the chemical properties vary in a monotonic manner, i.e., congeneric compounds share the same chemical property space. The chemical property space is a key component in molecular design, where some building blocks are functionalized, i.e., derivatized, and eventually self-assembled in more complex systems, such as enzyme-ligand systems, of which (physico-chemical) properties/bioactivity may be predicted by QSPR/QSAR (quantitative structure-property/activity relationship) studies. The system structu

SUBMITTER: Lungu CN 

PROVIDER: S-EPMC4849011 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature