Prognostic Value of MicroRNAs in Preoperative Treated Rectal Cancer.

ABSTRACT:

Background

Patients with locally advanced rectal cancer are treated with preoperative chemoradiotherapy followed by surgical resection. Despite similar clinical parameters (uT2-3, uN+) and standard therapy, patients' prognoses differ widely. A possible prediction of prognosis through microRNAs as biomarkers out of treatment-naïve biopsies would allow individualized therapy options.

Methods

Microarray analysis of 45 microdissected preoperative biopsies from patients with rectal cancer was performed to identify potential microRNAs to predict overall survival, disease-free survival, cancer-specific survival, distant-metastasis-free survival, tumor regression grade, or nodal stage. Quantitative real-time polymerase chain reaction (qPCR) was performed on an independent set of 147

SUBMITTER: Azizian A 

PROVIDER: S-EPMC4849024 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature