Effect of age and sex on efficacy and tolerability of β blockers in patients with heart failure with reduced ejection fraction: individual patient data meta-analysis.

ABSTRACT:

Objectives

To determine the efficacy and tolerability of β blockers in a broad age range of women and men with heart failure with reduced ejection fraction (HFrEF) by pooling individual patient data from placebo controlled randomised trials.

Design

Prospectively designed meta-analysis of individual patient data from patients aged 40-85 in sinus rhythm at baseline, with left ventricular ejection fraction <0.45.

Participants

13,833 patients from 11 trials; median age 64; 24% women.

Main outcome measures

The primary outcome was all cause mortality; the major secondary outcome was admission to hospital for heart failure. Analysis was by intention to treat with an adjusted one stage Cox proportional hazards model.

Results

Compared with placebo, β blockers wer

SUBMITTER: Kotecha D 

PROVIDER: S-EPMC4849174 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature