The Uterine Immune Profile May Help Women With Repeated Unexplained Embryo Implantation Failure After In Vitro Fertilization.

ABSTRACT:

Labeled problem

Embryo implantation remains the main limiting factor in assisted reproductive medicine (20% success rate).

Methods of study

An endometrial immune profiling was performed among 394 women with the previous history of repeated embryo implantation failures (RIF). The endometrial immune profile documented the ratio of IL-15/Fn-14 mRNA as a biomarker of uNK cell activation/maturation (together with the uNK cell count) and the IL-18/TWEAK mRNA ratio as a biomarker of both angiogenesis and the Th1/Th2 balance. According to their profile, we recommended personalized care to counteract the documented dysregulation and assessed its effects by the live birth rate (LBR) for the next embryo transfer.

Results

Endometrial immune profiles appeared to be dysregulated in

SUBMITTER: Ledee N 

PROVIDER: S-EPMC4849202 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature