Anhedonia in the psychosis risk syndrome: associations with social impairment and basal orbitofrontal cortical activity.

ABSTRACT:

Background/objectives

Anhedonia is associated with poor social function in schizophrenia. Here, we examined this association in individuals at clinical high risk (CHR) for schizophrenia and related psychotic disorders, taking into account social anxiety. We then explored correlations between anhedonia and basal metabolic activity in selected forebrain regions implicated in reward processing.

Methods

In 62 CHR individuals and 37 healthy controls, we measured social adjustment (Social Adjustment Self-Report Scale), social and physical anhedonia (Chapman Revised Anhedonia Scales), and social anxiety (Social Anxiety Scale for Adolescents) in cross-section. In a subgroup of 25 CHR individuals for whom high-spatial-resolution basal-state functional magnetic resonance imaging data

SUBMITTER: Cressman VL 

PROVIDER: S-EPMC4849450 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature