Lower prefrontal activation during emotion regulation in subjects at ultrahigh risk for psychosis: an fMRI-study.

ABSTRACT:

Background

Previous research has shown that patients with schizophrenia experience difficulties with emotion regulation and activate prefrontal regions to a lesser extent during reappraisal of emotional information. It has been suggested that problems in emotion regulation might precede the onset of psychosis. Therefore, it could be hypothesized that also individuals at ultrahigh risk (UHR) for developing psychosis experience difficulties with emotion regulation.

Aims

The aim of the current study was to investigate whether individuals at UHR for developing psychosis show abnormal brain activation during reappraisal of negative pictures.

Methods

Using functional magnetic resonance imaging (fMRI), we scanned 15 UHR participants and 16 matched healthy controls while perf

SUBMITTER: van der Velde J 

PROVIDER: S-EPMC4849453 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature