Functional magnetic resonance spectroscopy of glutamate in schizophrenia and major depressive disorder: anterior cingulate activity during a color-word Stroop task.

ABSTRACT:

Background

Glutamate abnormalities have been suggested to be associated with symptoms of schizophrenia. Using functional magnetic resonance spectroscopy ((1)H-fMRS), it is possible to monitor glutamate dynamically in the activated brain areas, which has yet to be reported in schizophrenia. It was hypothesized that subjects with schizophrenia would have weaker glutamatergic responses in the anterior cingulate to a color-word Stroop Task.

Aims

The aim of this study was to gain insight into the health of GLU neurotransmission and the GLU-GLN cycle in SZ using a (1)H-fMRS protocol.

Methods

Spectra were acquired from the anterior cingulate of 16 participants with schizophrenia, 16 healthy controls and 16 participants with major depressive disorder (MDD) while performing th

SUBMITTER: Taylor R 

PROVIDER: S-EPMC4849454 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature