Does Celiac Disease Influence Survival in Sepsis? A Nationwide Longitudinal Study.

ABSTRACT:

Background

Individuals with celiac disease (CD) are at increased risk of sepsis. The aim of this study was to examine whether CD influences survival in sepsis of bacterial origin.

Methods

Nationwide longitudinal registry-based study. Through data on small intestinal biopsies from Sweden's 28 pathology departments, we identified 29,096 individuals with CD (villous atrophy, Marsh stage III). Each individual with CD was matched with five population-based controls. Among these, 5,470 had a record of sepsis according to the Swedish Patient Register (1,432 celiac individuals and 4,038 controls). Finally we retrieved data on mortality in sepsis patients through the Swedish Cause of Death Registry.

Results

CD was associated with a 19% increase in overall mortality after sepsi

SUBMITTER: Rockert Tjernberg A 

PROVIDER: S-EPMC4849637 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature