Orthostatic Hypotension and Elevated Resting Heart Rate Predict Low-Energy Fractures in the Population: The Malmo Preventive Project.

ABSTRACT:

Background

Autonomic disorders of the cardiovascular system, such as orthostatic hypotension and elevated resting heart rate, predict mortality and cardiovascular events in the population. Low-energy-fractures constitute a substantial clinical problem that may represent an additional risk related to such autonomic dysfunction.

Aims

To test the association between orthostatic hypotension, resting heart rate and incidence of low-energy-fractures in the general population.

Methods and results

Using multivariable-adjusted Cox regression models we investigated the association between orthostatic blood pressure response, resting heart rate and first incident low-energy-fracture in a population-based, middle-aged cohort of 33 000 individuals over 25 years follow-up. The medi

SUBMITTER: Hamrefors V 

PROVIDER: S-EPMC4849675 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature