The wMel Strain of Wolbachia Reduces Transmission of Chikungunya Virus in Aedes aegypti.

ABSTRACT:

Background

New approaches to preventing chikungunya virus (CHIKV) are needed because current methods are limited to controlling mosquito populations, and they have not prevented the invasion of this virus into new locales, nor have they been sufficient to control the virus upon arrival. A promising candidate for arbovirus control and prevention relies on the introduction of the intracellular bacterium Wolbachia into Aedes aegypti mosquitoes. This primarily has been proposed as a tool to control dengue virus (DENV) transmission; however, evidence suggests Wolbachia infections confer protection for Ae. aegypti against CHIKV. Although this approach holds much promise for limiting virus transmission, at present our understanding of the ability of CHIKV to infect, disseminate, and be tr

SUBMITTER: Aliota MT 

PROVIDER: S-EPMC4849757 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature