Principles and Overview of Sampling Methods for Modeling Macromolecular Structure and Dynamics.

ABSTRACT: Investigation of macromolecular structure and dynamics is fundamental to understanding how macromolecules carry out their functions in the cell. Significant advances have been made toward this end in silico, with a growing number of computational methods proposed yearly to study and simulate various aspects of macromolecular structure and dynamics. This review aims to provide an overview of recent advances, focusing primarily on methods proposed for exploring the structure space of macromolecules in isolation and in assemblies for the purpose of characterizing equilibrium structure and dynamics. In addition to surveying recent applications that showcase current capabilities of computational methods, this review highlights state-of-the-art algorithmic techniques proposed to overcome challen

SUBMITTER: Maximova T 

PROVIDER: S-EPMC4849799 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature