Regulation of Vascular Smooth Muscle Cell Dysfunction Under Diabetic Conditions by miR-504.

ABSTRACT:

Objective

Diabetes mellitus accelerates proatherogenic and proinflammatory phenotype of vascular smooth muscle cell (VSMC) associated with vascular complications. Evidence shows that microRNAs (miRNAs) play key roles in VSMC functions, but their role under diabetic conditions is unclear. We profiled miRNAs in VSMC from diabetic mice and examined their role in VSMC dysfunction.

Approach and results

High throughput small RNA-sequencing identified 135 differentially expressed miRNAs in VSMC from type 2 diabetic db/db mice (db/dbVSMC) versus nondiabetic db/+ mice. Several of these miRNAs were known to regulate VSMC functions. We further focused on miR-504, because it was highly upregulated in db/dbVSMC, and its function in VSMC is unknown. miR-504 and its host gene Fgf13 were si

SUBMITTER: Reddy MA 

PROVIDER: S-EPMC4850084 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature