Heritability of ECG Biomarkers in the Netherlands Twin Registry Measured from Holter ECGs.

ABSTRACT:

Introduction

The resting ECG is the most commonly used tool to assess cardiac electrophysiology. Previous studies have estimated heritability of ECG parameters based on these snapshots of the cardiac electrical activity. In this study we set out to determine whether analysis of heart rate specific data from Holter ECGs allows more complete assessment of the heritability of ECG parameters.

Methods and results

Holter ECGs were recorded from 221 twin pairs and analyzed using a multi-parameter beat binning approach. Heart rate dependent estimates of heritability for QRS duration, QT interval, Tpeak-Tend and Theight were calculated using structural equation modeling. QRS duration is largely determined by environmental factors whereas repolarization is primarily genetically determ

SUBMITTER: Hodkinson EC 

PROVIDER: S-EPMC4850154 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature