Computational Study of Thrombus Formation and Clotting Factor Effects under Venous Flow Conditions.

ABSTRACT: A comprehensive understanding of thrombus formation as a physicochemical process that has evolved to protect the integrity of the human vasculature is critical to our ability to predict and control pathological states caused by a malfunctioning blood coagulation system. Despite numerous investigations, the spatial and temporal details of thrombus growth as a multicomponent process are not fully understood. Here, we used computational modeling to investigate the temporal changes in the spatial distributions of the key enzymatic (i.e., thrombin) and structural (i.e., platelets and fibrin) components within a growing thrombus. Moreover, we investigated the interplay between clot structure and its mechanical properties, such as hydraulic resistance to flow. Our model relied on the coupling of

SUBMITTER: Govindarajan V 

PROVIDER: S-EPMC4850327 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature