Breast milk-acquired cytomegalovirus infection and disease in VLBW and premature infants.

ABSTRACT:

Background

Very low birth weight (VLBW) and premature infants are at risk for developing postnatal cytomegalovirus (CMV) disease, including CMV-related sepsis-like syndrome (CMV-SLS) for which estimates [corrected] in the United States are lacking.

Methods

We performed a systematic review and meta-analysis to estimate the pooled proportions (and 95% confidence intervals) of VLBW and premature infants born to CMV-seropositive women with breast milk-acquired CMV infection and CMV-SLS. We combined these proportions with population-based rates of CMV seropositivity, breast milk feeding, VLBW, and prematurity to estimate annual rates of breast milk-acquired CMV infection and CMV-SLS in the United States.

Results

In our meta-analysis, among 299 infants fed untreated breast

SUBMITTER: Lanzieri TM 

PROVIDER: S-EPMC4850548 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature