Clinical and pathological features of BRCA1/2 tumors in a sample of high-risk Moroccan breast cancer patients.

ABSTRACT:

Background

BRCA1 and BRCA2 genes explain a large part of hereditary breast cancer. Several studies have shown that BRCA1 and BRCA2 tumors exhibit some specific morphological and immunohistochemical characteristics. The aim of our study is to compare the clinicopathological characteristics between Moroccan breast cancers associated or not with BRCA1 and BRCA2 mutations. Previously, we had identified 11 BRCA carriers in a series of 40 selected breast cancer patients at increased risk for carrying a mutation in the BRCA1 and BRCA2 genes. The clinical and pathological features of patients carrying BRCA1 or BRCA2 mutation (n = 11) were evaluated and compared to those of non-mutated patients (n = 29).

Results

In comparison with non carriers, women with BRCA1/2 mutation present you

SUBMITTER: Jouhadi H 

PROVIDER: S-EPMC4850715 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature