PDGFRβ Is a Novel Marker of Stromal Activation in Oral Squamous Cell Carcinomas.

ABSTRACT: Carcinoma associated fibroblasts (CAFs) form the main constituents of tumor stroma and play an important role in tumor growth and invasion. The presence of CAFs is a strong predictor of poor prognosis of head and neck squamous cell carcinoma. Despite significant progress in determining the role of CAFs in tumor progression, the mechanisms contributing to their activation remain poorly characterized, in part due to fibroblast heterogeneity and the scarcity of reliable fibroblast surface markers. To search for such markers in oral squamous cell carcinoma (OSCC), we applied a novel approach that uses RNA-sequencing data derived from the cancer genome atlas (TCGA). Specifically, our strategy allowed for an unbiased identification of genes whose expression was closely associated with a set of b

SUBMITTER: Kartha VK 

PROVIDER: S-EPMC4851360 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature