Genetic Variation in Autophagy-Related Genes Influences the Risk and Phenotype of Buruli Ulcer.

ABSTRACT:

Introduction

Buruli ulcer (BU) is a severe necrotizing human skin disease caused by Mycobacterium ulcerans. Clinically, presentation is a sum of these diverse pathogenic hits subjected to critical immune-regulatory mechanisms. Among them, autophagy has been demonstrated as a cellular process of critical importance. Since microtubules and dynein are affected by mycolactone, the critical pathogenic exotoxin produced by M. ulcerans, cytoskeleton-related changes might potentially impair the autophagic process and impact the risk and progression of infection.

Objective

Genetic variants in the autophagy-related genes NOD2, PARK2 and ATG16L1 has been associated with susceptibility to mycobacterial diseases. Here, we investigated their association with BU risk, its severe phenotypes

SUBMITTER: Capela C 

PROVIDER: S-EPMC4851401 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature