The ticking clock of Cayo Santiago macaques and its implications for understanding human circadian rhythm disorders.

ABSTRACT: The circadian clock disorders in humans remain poorly understood. However, their impact on the development and progression of major human conditions, from cancer to insomnia, metabolic or mental illness becomes increasingly apparent. Addressing human circadian disorders in animal models is, in part, complicated by inverse temporal relationship between the core clock and specific physiological or behavioral processes in diurnal and nocturnal animals. Major advantages of a macaque model for translational circadian research, as a diurnal vertebrate phylogenetically close to humans, are further emphasized by the discovery of the first familial circadian disorder in non-human primates among the rhesus monkeys originating from Cayo Santiago. The remarkable similarity of their pathological phenot

SUBMITTER: Zhdanova IV 

PROVIDER: S-EPMC4851432 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature