Whole Exome Sequencing of Chronic Myeloid Leukemia Patients.

ABSTRACT:

Background

Previous studies have shown that leukemogenic chromosomal translocations, including fusions between Break point Cluster Region (BCR) and Abelson (ABL) are present in the peripheral blood of healthy individuals. The aim of this study was to gain insights into the genetic alterations other than BCR-Abl translocation in molecular level, which cause chronic myeloid leukemia (CML).

Methods

We performed whole-exome sequencing on four cases representative of BCR-ABL positive CML in chronic phase of the disease.

Results

We did not identify any pathogenic mutation in all known genes involved in CML or other cancers in our subjects. Nevertheless, we identified polymorphisms in related genes.

Conclusion

It is the first report of exome sequencing in Philadelphia

SUBMITTER: Sabri S 

PROVIDER: S-EPMC4851749 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature