Surgical removal of endometriotic lesions alters local and systemic proinflammatory cytokines in endometriosis patients.

ABSTRACT:

Objective

To determine the impact of endometriotic lesion removal on local and systemic inflammation.

Design

Multiplex cytokine analysis on samples from endometriosis patients before surgery, 2 weeks after surgery, and 3 months after surgery.

Setting

Academic teaching hospital and university.

Patient(s)

A total of 43 endometriosis patients before and after excision of lesions by means of laparoscopic surgery, and 25 normal women.

Intervention(s)

None.

Main outcome measure(s)

Plasma, eutopic and ectopic tissue, and peritoneal fluid cytokine levels.

Result(s)

Compared with presurgery plasma samples, levels of granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin (IL) 2, IL-8, and IL-10 decreased significantly by 2 weeks after

SUBMITTER: Monsanto SP 

PROVIDER: S-EPMC4851862 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature