Subcutaneous nerve activity and mechanisms of sudden death in a rat model of chronic kidney disease.

ABSTRACT:

Background

The mechanisms of sudden death in chronic kidney disease (CKD) remain unclear.

Objective

The purpose of this study was to test the hypotheses that subcutaneous nerve activity (SCNA) can be used to estimate sympathetic tone in ambulatory rats and that abrupt reduction of SCNA precedes the spontaneous arrhythmic death of Cy/+ rats.

Methods

Radiotransmitters were implanted in ambulatory normal (N = 6) and Cy/+ (CKD; N = 6) rats to record electrocardiogram and SCNA. Two additional rats were studied before and after chemical sympathectomy with 6-hydroxydopamine.

Results

In normal rats, the baseline heart rate (HR) and SCNA were 351 ± 29 bpm and 5.12 ± 2.97 mV·s, respectively. SCNA abruptly increased HR by 4.31% (95% confidence interval 4.15%-4.47%). In co

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC4851901 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature