C-O bond Formation in a Microfluidic Reactor: High Yield S_NAr Substitution of Heteroaryl Chlorides.

ABSTRACT: This study describes our development of a novel and efficient procedure for C-O bond formation under mild conditions, for coupling heteroaryl chlorides with phenols or primary aliphatic alcohols. We utilized a continuous-flow microfluidic reactor for C-O bond formation in electron-deficient pyrimidines and pyridines in a much more facile manner with a cleaner reaction profile, high yield, quick scalability and without the need for the transition metal catalyst. This approach can be of general utility to make C-O bond containing intermediates of industrial importance in a continuous and safe manner.

SUBMITTER: Alam MP 

PROVIDER: S-EPMC4852388 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature