SepG coordinates sporulation-specific cell division and nucleoid organization in Streptomyces coelicolor.

ABSTRACT: Bacterial cell division is a highly complex process that requires tight coordination between septum formation and chromosome replication and segregation. In bacteria that divide by binary fission a single septum is formed at mid-cell, a process that is coordinated by the conserved cell division scaffold protein FtsZ. In contrast, during sporulation-specific cell division in streptomycetes, up to a hundred rings of FtsZ (Z rings) are produced almost simultaneously, dividing the multinucleoid aerial hyphae into long chains of unigenomic spores. This involves the active recruitment of FtsZ by the SsgB protein, and at the same time requires sophisticated systems to regulate chromosome dynamics. Here, we show that SepG is required for the onset of sporulation and acts by ensuring that SsgB is l

SUBMITTER: Zhang L 

PROVIDER: S-EPMC4852450 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature