ParA and ParB coordinate chromosome segregation with cell elongation and division during Streptomyces sporulation.

ABSTRACT: In unicellular bacteria, the ParA and ParB proteins segregate chromosomes and coordinate this process with cell division and chromosome replication. During sporulation of mycelial Streptomyces, ParA and ParB uniformly distribute multiple chromosomes along the filamentous sporogenic hyphal compartment, which then differentiates into a chain of unigenomic spores. However, chromosome segregation must be coordinated with cell elongation and multiple divisions. Here, we addressed the question of whether ParA and ParB are involved in the synchronization of cell-cycle processes during sporulation in Streptomyces To answer this question, we used time-lapse microscopy, which allows the monitoring of growth and division of single sporogenic hyphae. We showed that sporogenic hyphae stop extending at

SUBMITTER: Donczew M 

PROVIDER: S-EPMC4852455 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature