Analysis of Associations of Human BAFF Gene Polymorphisms with Autoimmune Thyroid Diseases.

ABSTRACT:

Background

The B-lymphocyte-activating factor (BAFF) is associated with B-cell functions, and gene polymorphisms of the BAFF have been linked to autoimmune diseases (AIDs). In this study, we explored possible associations of two BAFF single-nucleotide polymorphisms (SNPs), rs1041569 and rs2893321, with autoimmune thyroid diseases (AITDs) in an ethnic Chinese population.

Material and methods

In total, 319 Graves' disease (GD), 83 Hashimoto's thyroiditis (HT) patients, and 369 healthy controls were enrolled. Polymerase chain reaction-restriction fragment length polymorphism and direct sequencing were used to genotype rs2893321 and rs1041569.

Results

There was a significant difference in frequencies of the G allele and AG+GG genotype of rs2893321 between the GD and contr

SUBMITTER: Lin JD 

PROVIDER: S-EPMC4852922 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature