Atomoxetine does not alter cocaine use in cocaine dependent individuals: double blind randomized trial.

ABSTRACT:

Background

Cocaine abuse continues to be a significant public health problem associated with morbidity and mortality. To date, no pharmacotherapeutic approach has proven effective for treating cocaine use disorders. Preclinical and clinical evidence suggests that noradrenergic activity may play a role in mediating some effects of cocaine and may be a rational target for treatment.

Methods

This double blind, placebo-controlled randomized, parallel group, 12-week outpatient clinical trial enrolled cocaine dependent individuals seeking treatment to examine the potential efficacy of the selective norepinephrine reuptake inhibitor, atomoxetine (80 mg/day; p.o.; n = 25), compared to placebo (n = 25). Subjects were initially stratified on cocaine use (< 15 days or ≥ 15 days of the

SUBMITTER: Walsh SL 

PROVIDER: S-EPMC4852978 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature