Evidence of activation of the Toll-like receptor-4 proinflammatory pathway in patients with schizophrenia.

ABSTRACT:

Background

Alterations in the innate immune/inflammatory system may underlie the pathophysiology of schizophrenia, but we do not understand the mechanisms involved. The main agents of innate immunity are the Toll-like receptors (TLRs), which detect molecular patterns associated with damage and pathogens. The TLR first reported was TLR4, and it is still the most studied one.

Methods

We aimed to describe putative modifications to the TLR4 proinflammatory pathway using 2 different strategies in 2 cohorts of patients with schizophrenia and matched controls: 1) quantification of protein and mRNA expression in postmortem prefrontal cortex samples from 30 patients with schizophrenia and 30 controls, and 2) identification of single nucleotide polymorphisms associated with the risk o

SUBMITTER: Garcia-Bueno B 

PROVIDER: S-EPMC4853215 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature