A murine model of peripheral irradiation-induced fatigue.

ABSTRACT:

Purpose

Fatigue is the most ubiquitous side effect of cancer treatment, but its etiology remains elusive. Further investigations into cancer-related fatigue pathobiology necessitate the expanded use of animal models. This study describes the development of a murine model of radiation-induced fatigue.

Methods

Voluntary wheel running activity measured fatigue in 5-8 week-old, male C57BL/6 mice before and after γ irradiation totaling 2400cGy (3 consecutive days×800cGy daily fractionated doses) to the lower abdominal areas. Three trials confirmed fatigue behavior at this dose. Anhedonia, body weight, and hemoglobin were also measured. Gastrointestinal, skeletal muscle, and bone marrow tissue samples were evaluated for signs of damage.

Results

In two validation trials, irr

SUBMITTER: Renner M 

PROVIDER: S-EPMC4853268 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature