Interaction of MYC with host cell factor-1 is mediated by the evolutionarily conserved Myc box IV motif.

ABSTRACT: The MYC family of oncogenes encodes a set of three related transcription factors that are overexpressed in many human tumors and contribute to the cancer-related deaths of more than 70,000 Americans every year. MYC proteins drive tumorigenesis by interacting with co-factors that enable them to regulate the expression of thousands of genes linked to cell growth, proliferation, metabolism and genome stability. One effective way to identify critical co-factors required for MYC function has been to focus on sequence motifs within MYC that are conserved throughout evolution, on the assumption that their conservation is driven by protein-protein interactions that are vital for MYC activity. In addition to their DNA-binding domains, MYC proteins carry five regions of high sequence conservation kn

SUBMITTER: Thomas LR 

PROVIDER: S-EPMC4853269 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature