The genetic predisposition to bronchopulmonary dysplasia.

ABSTRACT:

Purpose of review

Bronchopulmonary dysplasia (BPD) is a prevalent chronic lung disease in premature infants. Twin studies have shown strong heritability underlying this disease; however, the genetic architecture of BPD remains unclear.

Recent findings

A number of studies employed different approaches to characterize the genetic aberrations associated with BPD, including candidate gene studies, genome-wide association studies, exome sequencing, integrative omics analysis, and pathway analysis. Candidate gene studies identified a number of genes potentially involved with the development of BPD, but the etiological contribution from each gene is not substantial. Copy number variation studies and three independent genome-wide association studies did not identify genetic variatio

SUBMITTER: Yu KH 

PROVIDER: S-EPMC4853271 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature