Association of COL1A1 polymorphism with high myopia: a Meta-analysis.

ABSTRACT:

Aim

To investigate the association between collagen type I alpha 1 (COL1A1) gene and high myopia.

Methods

In this Meta-analysis, we examined 5 published case-control studies that involved 1942 high myopia cases and 2929 healthy controls to assess the association between the COL1A1 rs2075555 polymorphism and high myopia risk. We calculated the pooled odds ratios (ORs) of COL1A1 rs2075555 polymorphism in high myopia cases vs healthy controls to evaluate the strength of the association.

Results

Overall, there was no significant difference both in the genotype and allele distributions of COL1A1 rs2075555 polymorphism between high myopia cases and healthy controls: CC vs AA OR=1.10, 95% confidence interval (CI)=0.76-1.58; AC vs AA OR=0.98, 95%CI 0.80-1.20; CC/AC vs AA/OR=1

SUBMITTER: Jin GM 

PROVIDER: S-EPMC4853360 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature