Expression of the Components of the Renin-Angiotensin System in Venous Malformation.

ABSTRACT:

Background

Venous malformation (VM) is the most common form of vascular malformation, consisting of a network of thin-walled ectatic venous channels with deficient or absent media. This study investigated the expression of the components of the renin-angiotensin system (RAS), namely, (pro)renin receptor (PRR), angiotensin-converting enzyme (ACE), angiotensin II receptor 1 (ATIIR1), and angiotensin II receptor 2 (AIITR2) in subcutaneous (SC) and intramuscular (IM) VM.

Materials and methods

SC (n = 7) and IM (n = 7) VM were analyzed for the expression of PRR, ACE, ATIIR1, and ATIIR2 using 3,3-diaminobenzidine and immunofluorescent (IF) immunohistochemical (IHC) staining and NanoString gene expression analysis.

Results

IHC staining showed expression of PRR, ACE, and ATII

SUBMITTER: Siljee S 

PROVIDER: S-EPMC4853390 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature