Reducing slab boundary artifacts in three-dimensional multislab diffusion MRI using nonlinear inversion for slab profile encoding (NPEN).

ABSTRACT:

Purpose

To propose a method to reduce the slab boundary artifacts in three-dimensional multislab diffusion MRI.

Methods

Bloch simulation is used to investigate the effects of multiple factors on slab boundary artifacts, including characterization of residual errors on diffusion quantification. A nonlinear inversion method is proposed to simultaneously estimate the slab profile and the underlying (corrected) image.

Results

Correction results of numerical phantom and in vivo data demonstrate that the method can effectively remove slab boundary artifacts for diffusion data. Notably, the nonlinear inversion is also successful at short TR, a regimen where previously proposed methods (slab profile encoding and weighted average) retain residual artifacts in both diffusion-we

SUBMITTER: Wu W 

PROVIDER: S-EPMC4854328 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature