PI3K/AKT Signaling Pathway Is Essential for Survival of Induced Pluripotent Stem Cells.

ABSTRACT: Apoptosis is a highly conserved biochemical mechanism which is tightly controlled in cells. It contributes to maintenance of tissue homeostasis and normally eliminates highly proliferative cells with malignant properties. Induced pluripotent stem cells (iPSCs) have recently been described with significant functional and morphological similarities to embryonic stem cells. Human iPSCs are of great hope for regenerative medicine due to their broad potential to differentiate into specialized cell types in culture. They may be useful for exploring disease mechanisms and may provide the basis for future cell-based replacement therapies. However, there is only poor insight into iPSCs cell signaling as the regulation of apoptosis. In this study, we focused our attention on the apoptotic response o

SUBMITTER: Hossini AM 

PROVIDER: S-EPMC4854383 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature