Adipokine Imbalance in the Pericardial Cavity of Cardiac and Vascular Disease Patients.

ABSTRACT:

Aim

Obesity and especially hypertrophy of epicardial adipose tissue accelerate coronary atherogenesis. We aimed at comparing levels of inflammatory and atherogenic hormones from adipose tissue in the pericardial fluid and circulation of cardiovascular disease patients.

Methods and results

Venous plasma (P) and pericardial fluid (PF) were obtained from elective cardiothoracic surgery patients (n = 37). Concentrations of leptin, adipocyte fatty acid-binding protein (A-FABP) and adiponectin (APN) were determined by enzyme-linked immunosorbent assays (ELISA). The median concentration of leptin in PF (4.3 (interquartile range: 2.8-9.1) μg/L) was comparable to that in P (5.9 (2.2-11) μg/L) and these were significantly correlated to most of the same patient characteristics. The con

SUBMITTER: Elie AG 

PROVIDER: S-EPMC4854456 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature