Systemic Correlates of White Adipose Tissue Inflammation in Early-Stage Breast Cancer.

ABSTRACT:

Purpose

Obesity, insulin resistance, and elevated levels of circulating proinflammatory mediators are associated with poorer prognosis in early-stage breast cancer. To investigate whether white adipose tissue (WAT) inflammation represents a potential unifying mechanism, we examined the relationship between breast WAT inflammation and the metabolic syndrome and its prognostic importance.

Experimental design

WAT inflammation was defined by the presence of dead/dying adipocytes surrounded by macrophages forming crown-like structures (CLS) of the breast. Two independent groups were examined in cross-sectional (cohort 1) and retrospective (cohort 2) studies. Cohort 1 included 100 women undergoing mastectomy for breast cancer risk reduction (n = 10) or treatment (n = 90). Metaboli

SUBMITTER: Iyengar NM 

PROVIDER: S-EPMC4854755 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature