Chromosomal Instability Affects the Tumorigenicity of Glioblastoma Tumor-Initiating Cells.

ABSTRACT:

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Tumors are dynamic organs that evolve during disease progression with genetic, epigenetic, and environmental differences among tumor cells serving as the foundation for selection and evolution in tumors. Tumor-initiating cells (TIC) that are responsible for tumorigenesis are a source of functional cellular heterogeneity, whereas chromosomal instability (CIN) is a source of karyotypic genetic diversity. However, the extent that CIN contributes to TIC genetic diversity and its relationship to TIC function remains unclear. Here, we demonstrate that glioblastoma TICs display CIN with lagging chromosomes at anaphase and extensive nonclonal chromosome copy-number variations. Elevating the basal chromosome missegregation rate in TICs decreases both proliferation and the stem-li

SUBMITTER: Godek KM 

PROVIDER: S-EPMC4854766 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature