Genetic Effect of Chemotherapy Exposure in Children of Testicular Cancer Survivors.

ABSTRACT:

Purpose

Cancer survivors express anxiety that chemotherapy exposure may lead to transmissible genetic damage in posttreatment children. Preclinical models suggest that chemotherapy exposure may result in considerable genomic alterations in postexposure progeny. Epidemiologic studies have not demonstrated a significant increase in congenital abnormalities in posttreatment children of cancer survivors, but the inherited genome-wide effect of chemotherapy exposure in humans is unknown.

Experimental design

Two testicular cancer survivors cured with chemotherapy who had children pre- and postexposure without sperm banking were identified. Familial germline whole genome sequencing (WGS) was performed for these families, and analytic methods were utilized to identify de novo altera

SUBMITTER: Kryukov GV 

PROVIDER: S-EPMC4854770 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature