Heterogeneity of Programmed Cell Death Ligand 1 Expression in Multifocal Lung Cancer.

ABSTRACT:

Purpose

The expression of programmed cell death ligand 1 (PD-L1) provides limited predictive value in identifying patients most likely to respond to immunotherapy. As the heterogeneity of PD-L1 expression may lead to sampling error and the misclassification of PD-L1 status, we assessed the distribution of PD-L1 expression in paired, resected multifocal lung cancers.

Experimental design

PD-L1 was assessed by IHC. Paired lesions were defined as independent primaries or related lesions using mate pair next-generation sequencing. Agreement statistics were used for analysis.

Results

Sixty-seven multifocal lung cancers from 32 patients were sequenced and stained for PD-L1. There was agreement of PD-L1 expression by the tumor cells in paired lesions of 20 patients and disagr

SUBMITTER: Mansfield AS 

PROVIDER: S-EPMC4854782 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature