Probiotic Administration in Infants With Gastroschisis: A Pilot Randomized Placebo-Controlled Trial.

ABSTRACT:

Objectives

Infants with gastroschisis often require long periods of gastric suctioning and hospitalization. The impact of these interventions on the intestinal microbiota and attempts to alter the microbial community have not been studied. We sought to determine how the intestinal microbiota is influenced by the current treatment of gastroschisis and whether alteration of the intestinal microbiota with a probiotic microbe will influence length of hospitalization.

Methods

We performed a randomized, placebo-controlled pilot study of administration of probiotic Bifidobacterium longum subsp. infantis in 24 infants with gastroschisis. The primary outcome was changes in the fecal microbiota, and the secondary outcome was length of hospital stay.

Results

Administration of th

SUBMITTER: Powell WT 

PROVIDER: S-EPMC4854817 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature