Gene and transposable element methylation in great tit (Parus major) brain and blood.

ABSTRACT:

Background

Studies on vertebrate DNA methylomes have revealed a regulatory role of tissue specific DNA methylation in relation to gene expression. However, it is not well known how tissue-specific methylation varies between different functional and structural components of genes and genomes. Using whole-genome bisulfite sequencing data we here describe both CpG and non-CpG methylation profiles of whole blood and brain tissue in relation to gene features, CpG-islands (CGIs), transposable elements (TE), and their functional roles in an ecological model species, the great tit (Parus major).

Results

We show that hypomethylation at the transcription start site (TSS) is enriched in genes with functional classes that relate directly to processes specific to each tissue type. We fin

SUBMITTER: Derks MF 

PROVIDER: S-EPMC4855439 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature