Cognitive performance and neuropsychiatric symptoms in early, untreated Parkinson's disease.

ABSTRACT:

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This study was undertaken to determine the prevalence and correlates of cognitive impairment (CI) and neuropsychiatric symptoms (NPS) in early, untreated patients with Parkinson's disease (PD).

Background

Both CI and NPS are common in PD and impact disease course and quality of life. However, limited knowledge is available about cognitive abilities and NPS.

Methods

Parkinson's Progression Markers Initiative (PPMI) is a multi-site study of early, untreated PD patients and healthy controls (HCs), the latter with normal cognition. At baseline, participants were assessed with a neuropsychological battery and for symptoms of depression, anxiety, impulse control disorders (ICDs), psychosis, and apathy.

Results

Baseline data of 423 PD patients and 196 HCs y

SUBMITTER: Weintraub D 

PROVIDER: S-EPMC4855523 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature