Striatal structure and function predict individual biases in learning to avoid pain.

ABSTRACT: Pain is an elemental inducer of avoidance. Here, we demonstrate that people differ in how they learn to avoid pain, with some individuals refraining from actions that resulted in painful outcomes, whereas others favor actions that helped prevent pain. These individual biases were best explained by differences in learning from outcome prediction errors and were associated with distinct forms of striatal responses to painful outcomes. Specifically, striatal responses to pain were modulated in a manner consistent with an aversive prediction error in individuals who learned predominantly from pain, whereas in individuals who learned predominantly from success in preventing pain, modulation was consistent with an appetitive prediction error. In contrast, striatal responses to success in prevent

SUBMITTER: Eldar E 

PROVIDER: S-EPMC4855606 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature