Immuno-Navigator, a batch-corrected coexpression database, reveals cell type-specific gene networks in the immune system.

ABSTRACT: High-throughput gene expression data are one of the primary resources for exploring complex intracellular dynamics in modern biology. The integration of large amounts of public data may allow us to examine general dynamical relationships between regulators and target genes. However, obstacles for such analyses are study-specific biases or batch effects in the original data. Here we present Immuno-Navigator, a batch-corrected gene expression and coexpression database for 24 cell types of the mouse immune system. We systematically removed batch effects from the underlying gene expression data and showed that this removal considerably improved the consistency between inferred correlations and prior knowledge. The data revealed widespread cell type-specific correlation of expression. Integrate

SUBMITTER: Vandenbon A 

PROVIDER: S-EPMC4855614 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature