A transcriptional signature of Alzheimer's disease is associated with a metastable subproteome at risk for aggregation.

ABSTRACT: It is well-established that widespread transcriptional changes accompany the onset and progression of Alzheimer's disease. Because of the multifactorial nature of this neurodegenerative disorder and its complex relationship with aging, however, it remains unclear whether such changes are the result of nonspecific dysregulation and multisystem failure or instead are part of a coordinated response to cellular dysfunction. To address this problem in a systematic manner, we performed a meta-analysis of about 1,600 microarrays from human central nervous system tissues to identify transcriptional changes upon aging and as a result of Alzheimer's disease. Our strategy to discover a transcriptional signature of Alzheimer's disease revealed a set of down-regulated genes that encode proteins metasta

SUBMITTER: Ciryam P 

PROVIDER: S-EPMC4855616 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature